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(PDF) Bioreactor Design - ResearchGate

6.2 BIOREACTORS BACKGROUND. The main objective of a properly designed bioreactor is to pr ovide a controlled environment to. . Small openings must be made lea k-proof with an O-ring, .

Bioreactors - an overview | ScienceDirect Topics

L.E. Erickson, in Encyclopedia of Microbiology (Third Edition), 2009. Bioreactors are vessels or tanks in which whole cells or cell-free enzymes transform raw materials into biochemical products and/or less undesirable by-products. The microbial cell itself is a miniature bioreactor; other examples include shake flasks, Petri dishes, and industrial fermentors.

Fermentation & Bioreactors | Sartorius

Discover the broadest selection of bioreactors & fermenters in the industry. Scalable from 8 mL up to 2,000 L, single-use or made from stainless steel!

A Small-Footprint, Integrated, and Automated Platform for .

The process was developed at small scale (scale-X hydro bioreactor, 2.4 m² growth surface) and is being scaled-up to pilot scale (scale-X carbo bioreactor, 10–30 m² growth surface).

Airlift Bioreactors - an overview | ScienceDirect Topics

Hesham A. El-Enshasy, in Bioprocessing for Value-Added Products from Renewable Resources, 2007. 5.1.7 Bioreactor type. Yin et al. [151] studied the cultivation of R. oryzae in a shake flask and in an air-lift bioreactor. When the inoculated spore concentrations were between 2×105 and 2×106 spores mL-1, cell morphology appeared as reduced fluffy and pellet mycelia, respectively.

Allegro™ XRS 25 Bioreactor System | Pall Shop

Under similar agitation conditions, the Allegro XRS 25 bioreactor system mixes almost 3 times faster than conventional rockers (Table 1), and demonstrates much higher mass transfer properties as measured by k L a values (Table 2).

HyPerforma Single-Use Mixers | Thermo Fisher Scientific - US

The Thermo Scientific HyPerforma Single-Use Mixer (S.U.M.) has been designed using a proven engineered mixer platform design and offers a more ergonomic and efficient user experience for upstream and downstream mixing applications.The complete line of HyPerforma S.U.M.s includes 50, 100, 200, 500, 1,000 and 2,000 L .

Fermenters and Bioreactors | New and Used Lab Fermenters .

Industrial-scale fermenters, or bioreactors, are used for propagation of organisms for protein synthesis, or production of chemicals or drugs from chemical precursors. The scale, adaptability, and suitability are important considerations, as well as the requirements involved in breakdown and maintenance.

Development of a Scale-Down Model for rAAV Viral Vector .

same amount of bioreactors in one week whereas it takes two weeks in 2 L glass bioreactors." Using the DASbox system also helped reduce costs, by facilitating the performance of studies in small-scale bioreactors. A 1x105 1x106 02 448 72 V i a b l e a c e l l s e / m L Time (h) 300 rpm 400 rpm 375 rpm 2 L bioreactor, 180 rpm (n=6) B 2 14 16 .

Stainless Steel Bioreactors - Applikon Biotechnology

The microbial Sterilizable-In-Place bioreactor systems come in a total volume of 15 L, 20 L, 30 L, 40 L, 70 L and 140 L. The cell culture Sterilizable-In-Place bioreactor systems come in a total volume of 15 L, 20 L, 30 L, 60 L and 130 L. The main difference between these two lines is the aspect ratio of the bioreactors.

4 Process Involved in Scale up Criteria | Microbial .

Oxygen is only sparingly solube in cell culture medium (0.2 m mole O 2 I-1). Oxygen demand of a culture (10 6 cells per ml) ranges between 0.053 m mole O 2 l-1 h-1 and 0.59 m mole O 2 I-1 h-1 depending on the type of cell. Scale up of mammalian cell cultures are, therefore, bound by .

ambr Minibioreactors for Intensified Cell Culture .

According to a 2018 survey (2), over 80% of the biopharmaceutical industry uses Sartorius Stedim Biotech's (SSB) ambr micro- and ambr minibioreactors as mimics of benchtop bioreactors for fed-batch and batch cell culture.To date, more than 400 .

High quality glass autoclavalbe bioreactors and fermentors

The stirred tank reactor (STR) is the most widely used bioreactor type. Glass autoclavable bioreactors and fermentors are available in jacketed and single wall versions in 2, 3, 5, 7, 15 and 20 liter total volume (20 liter only in single wall version).


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Mobius® 3L Single-use Bioreactor - Mobius Mixing Systems

Eliminate the need to clean, autoclave and assemble your traditional glass bioreactors and save days of downtime with the Mobius® 3L Single-use Bioreactor. - Find MSDS or SDS, a COA, data sheets and more information.

Keys to successful single-use bioreactor scale up – from .

In the poster, authors used BioBLU Single-Use Vessels of different sizes (maximum working volumes of 0.25 L, 3.75 L, and 40 L) that are of geometrically similar stirred-tank design to scale up a mAb CHO process from small to pilot scale production. Bioreactor Scale Up Considerations

Single-use Bioreactors | Cytiva, formerly GE Healthcare .

Simplifying cell culture expansion: From cell bank vial to 2000 L production bioreactor in a single step; Bioburden sources you might have missed; Application notes and posters. Efficient, high-titer monoclonal antibody production in a fed-batch process using single-use stirred-tank and rocking bioreactor systems

Chapter 10: Sterilization and Bioreactor Operation

A 10,000 liter (of liquid) bioreactor contains 5 g /L of growing cells q O 2 = 20 mmole O 2 /(g cells˜hr) D T = 2 m, D i = 1 m, (6-blade turbine agitator) x 3 blades For 1 liquid volume per minute aeration rate (air), can the OTR = OUR for N = 100 rpm? C L = 1 mg O 2 /L

BioBLU ® c Single-Use Vessels - Eppendorf International

BioBLU ® 0.3c Single-Use Vessel, cell culture, open pipe, 1 pitched-blade impeller, no pH, sterile, 4 pieces Catalog No. 1386100000

Single-use Stirred Tank Bioreactors

Improved handling - Reduced operator intervention and processing time. Excellent mixing performance - Shorter mixing times < 30 seconds and great power input for high kLa and CO 2 stripping . Optimized cleanroom footprint - Even the 2000 L bioreactor fits under 3 meters

Fermenter - Bioreactor | LAMBDA

MINIFOR laboratory fermentor and bioreactor. The LAMBDA MINIFOR bench-top autoclavable laboratory fermenter and bioreactor was developed as a result of the need to construct a small laboratory fermentor for working volume ranges from 35 ml to over 6 liters.. Based on long personal practical experience in fermentation and cell culture, a high quality fermentor-bioreactor which is .

Utah State University [email protected]

Utah State University [email protected] All Graduate Theses and Dissertations Graduate Studies 5-2011 Comparative Studies on Scale-Up Methods of Single-Use

Jupiter Autoclave 2 to 10L Bioreactors - Fermenters .

Jupiter Multi: a single unit is composed by a Master Control Station that includes a controller and 27" touchscreen monitor, capable of running one to twenty four bioreactors They are equipped with electric thermostating or hot water recirculation loop, for bacteria or cell cultures, different automation and process control grades, wide .

Bioreactor Fermentation and Cell Culture: Get it Right .

Apr 22, 2005 · NBS specializes in bioreactors in the 75- to 3,000-L range and somewhat smaller microbial fermentation vessels, focusing on biotech's "sweet spot": small to mid-sized manufacturers and sponsors with development-stage products that typically need equipment quickly, often within three months of concept.

Cell cultivation in the bioreactor - what should be .

Parallel bioreactor for small-scale cell culture bioprocesses. Vessels: 0,4 l - 1,0 l. Gentle magnetic stirring system capable of reaching up to 300 min –1. Optimum gassing with up to 5 MFCs. Up to six fully equipped bioreactors. eve® – Bioprocess software for bioreactors.

An Algae Bioreactor From Recycled Water Bottles : 7 Steps .

An Algae Bioreactor From Recycled Water Bottles: In this instructable, we describe how to build a photo-bioreactor that uses algae to convert carbon dioxide and sunlight into energy. The energy that is produced is in the form of algae biomass. The photo-bioreactor is built from plastic recycle.

PubMed - National Center for Biotechnology Information

We evaluated the sparger kLa and kLaCO2 (CO 2 volumetric mass transfer coefficient) from a range of bioreactor scales (3-2,000 L) with different spargers. Results demonstrated that kLa for oxygen is not an issue when scaling from small-scale to large-scale bioreactors at the same gas .

Mobius® 3L Single-use Bioreactor - Mobius Mixing Systems

Eliminate the need to clean, autoclave and assemble your traditional glass bioreactors and save days of downtime with the Mobius® 3L Single-use Bioreactor. - Find MSDS or SDS, a COA, data sheets and more information.

Bioreactors (Stirred-tank) / Fermentors | Biocompare.com

Bioreactor types range from small, 1-L benchtop units to 10,000-L systems for large-scale industrial applications, and can be batch type or continuous flow, in which materials flow constantly through the unit. Tight control over parameters such as temperature, moisture, pH, oxygen, and stirring rate will produce the most satisfactory results .

Mobius® Single-use Bioreactors | Single-use Manufacturing .

Scalable, Simple, Smart and Reliable. Mobius® Single-Use Bioreactors are a scalable portfolio of stirred tank bioreactors that provide flexibility by configuring software, hardware, and single-use assemblies for use in fed-batch and perfusion applications.. The Mobius® Bioreactor family includes the bench scale (3 L), pilot-scale (50 L and 200 L), and clinical scale (1000 L and 2000 L .